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目的:观察小剂量左旋甲状腺素对老年亚临床甲减并慢性心力衰竭患者心功能的影响。方法:33例诊断老年亚临床甲减并慢性心力衰竭患者,从6.25ug/d开始予口服左旋甲状腺素片,缓慢增加剂量,使血清促甲状腺素介于4-6mIU/L,观察1年。结果:服药12月时与服药前比较,超声心动图检查左室舒张末内径、左室收缩末内径明显缩小,射血分数明显增加,差异有显著性;服药6月、12月与治疗前比较,室速、室早明显减少,差异有统计学意义。血压、心率无明显变化;服药3月与服药前比较差异无统计学意义。结论:小剂量左旋甲状腺素补充治疗能明显改善老年亚临床甲减并慢性心力衰竭患者的心功能,增加射血分数,减少室速、室早的发生。
Objective: To observe the effects of low-dose levothyroxine on cardiac function in elderly patients with hypothyroidism and chronic heart failure. Methods: Thirty-three patients with subclinical hypothyroidism and chronic heart failure were treated with oral levothyroxine tablets starting from 6.25ug / d, and the dosage of thyroxine was slowly increased to 4-6mIU / L for 1 year. Results: Compared with before treatment, the left ventricular end-diastolic diameter and left ventricular end-systolic diameter were significantly decreased by echocardiography and the ejection fraction increased significantly at 12 months after taking the drug. There was significant difference between the two groups when taking medicine for 6 months and 12 months , Ventricular tachycardia, room early significantly reduced, the difference was statistically significant. No significant changes in blood pressure, heart rate; medication in March and before taking the difference was not statistically significant. CONCLUSIONS: Low-dose levothyroxine supplementation can significantly improve cardiac function, increase ejection fraction, and decrease ventricular tachycardia and ventricular contractions in elderly patients with hypothyroidism and chronic heart failure.