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他莫昔芬(三苯氧胺,Tamoxifen简写TMX)具有与克罗米芬相似的化学结构,是雌激素的拮抗剂。Klopper与Hall于1971年首次应用TMX诱发排卵,其后又有不少关于TMX诱发排卵的报道,其副作用少,对宫颈粘液影响较小,甚至比克罗米芬更有效,国内尚缺乏这方面的研究,本文对此进行初步探讨。 材料和方法 收集1990年8月～1991年4月在我科专科门诊就诊的41例月经失调或不孕的无排卵病人,初诊时询问病史,行全身和妇科检查,指导病人自测基础体温2～3个月,其间常规行内分泌激素测定[FSH(促性腺激素)、LH(黄体生成素)、E_2(雌二醇)、P(黄体酮)、PRL(催乳素)、T(睾酮)及T_3和T_4]、肝、肾功能和血、尿常规等检查,部分病人检查阴道细胞激素水平、B超、腹腔镜、子宫内膜活检,综合上述指标将这41例无排卵者分为三组:1.无排卵型功血10例,平均年龄26.8±6.14岁(21～36岁);2.多囊卵巢综合征18例,平均年龄28.44±3.47岁(22～35),3.卵巢功能低下,13
Tamoxifen (Tamoxifen abbreviated TMX) has a similar chemical structure to clomiphene and is an estrogen antagonist. Klopper and Hall first used TMX in 1971 to induce ovulation, followed by many reports on TMX-induced ovulation, with fewer side effects and less effect on cervical mucus, even more effective than clomiphene, which lacks research in this field , This article carries on preliminary discussion to this. Materials and Methods 41 cases of anovulatory patients with menstrual disorders or infertility who were treated in our department from August 1990 to April 1991 were enrolled. Patients were asked about their medical history at the time of their first visit and their whole body and gynecological examination were conducted to guide their self-test. ~ 3 months, during which routine determination of endocrine hormone [FSH, LH, E2, P (progesterone, PRL, T T_3 and T_4], liver and kidney function and blood, urine and other tests, some patients to check the level of vaginal cytokines, B ultrasound, laparoscopy, endometrial biopsy, the above indicators will be 41 cases of ovulation were divided into three groups : 1. Anovulatory dysfunctional uterine bleeding in 10 cases, the average age of 26.8 ± 6.14 years (21 to 36 years); 2. Polycystic ovary syndrome in 18 cases, mean age 28.44 ± 3.47 years (22 to 35), 3. Ovarian function Low, 13