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尼可兰迪(Nicorandil)具有扩张冠状动脉,降低心脏前、后负荷的作用,表明它适于治疗缺血性心脏病。为了评价本药治疗慢性稳定型心绞痛患者的作用,我们研究了口服单剂及每日两剂,共服两周进行治疗的患者在休息及运动时的血流动力学参数。 46例男性患者,有劳力性心绞痛史,发病时休息或舌下含服硝酸甘油可使心绞痛缓解,,Bruce运动试验由于出现症状持续时间<10分钟,伴有ST段压低1mm以上。有下列情况的患者不在研究范围内:需要预防性使用硝酸甘油或其他抗心绞痛药物者;高血压病,血压高于22.7/13.3kPa;继发于其他疾病的心绞痛;胰岛素依赖型糖尿病;肝肾疾病;心电图异常而影响ST段的分析者。
Nicorandil has the effect of dilating coronary arteries and reducing anterior and posterior cardiac load, suggesting that it is suitable for the treatment of ischemic heart disease. To assess the role of this drug in the treatment of patients with chronic stable angina pectoris, we studied the hemodynamic parameters at rest and during exercise in patients taking a single oral dose and two daily doses for a total of two weeks. 46 cases of male patients, history of exertional angina pectoris, resting or sublingual nitroglycerin on angina can reduce angina pectoris, Bruce exercise test due to symptoms of duration <10 minutes, accompanied by ST segment depression 1mm above. Patients were excluded from the study if prophylactic use of nitroglycerin or other anti-anginal drugs was required; hypertension, blood pressure higher than 22.7 / 13.3 kPa; angina secondary to other diseases; insulin-dependent diabetes mellitus; liver and kidney Disease; ECG abnormalities affect the ST segment of the analyst.