Reduced glutathione alleviates the toxic effect of 6-hydroxydopamine on bone marrow stromal cells

• 作 者: Henghui Wang Weifeng Luo Xiaoxia Wang Xiaoling Qin Shiyao Bao
• 机 构: Department of Neurology, the Second Affiliated Hospital of Soochow University, Suzhou 215004, Jiangs
• 出 处: 中国神经再生研究（英文版）
• 发表日期: 2011年22期
• 关键词: reduced glutathione 6-hydroxydopamine bone marrow stromal cells toxicity Parkins

We studied the effect of reduced glutathione on bone marrow stromal cells (BMSCs) treated with 6-hydroxydopamine (6-OHDA), which shows a toxic effect on dopaminergic neurons.The proliferation of BMSCs treated with 6-OHDA decreased, while that of BMSCs treated with reduced glutathione increased.The proliferation of BMSCs treated with both 6-OHDA and reduced glutathione was significantly higher compared with that treated with 6-OHDA alone.These findings indicate that reduced glutathione alleviates the toxic effect of 6-OHDA on BMSCs.