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目的检测妇科肿瘤术后下肢深静脉血栓形成的患者血浆中组织因子(TF)水平的变化,探讨其与妇科肿瘤术后深静脉血栓形成的相关性。方法用ELISA法分别检测妇科良恶性肿瘤术后无深静脉血栓形成患者与术后并发深静脉血栓形成患者组织因子(TF)血浆水平变化。结果无深静脉血栓形成的妇科恶性肿瘤组TF水平显著高于子宫肌瘤及健康对照组(P<0.01),子宫肌瘤与健康对照组比较差异无统计学意义(P>0.05)。深静脉血栓形成妇科恶性肿瘤组TF水平显著高于子宫肌瘤及健康对照组(P<0.01)。深静脉血栓形成的妇科恶性肿瘤组、子宫肌瘤与无深静脉血栓形成的妇科恶性肿瘤组、子宫肌瘤TF水平存在统计学差异(P<0.05)。结论妇科肿瘤术后深静脉血栓形成患者组织因子明显增高,组织因子可作为检测妇科肿瘤尤其是妇科恶性肿瘤术后深静脉血栓形成的指标之一。
Objective To investigate the changes of plasma tissue factor (TF) levels in patients with deep venous thrombosis after gynecologic oncology and to investigate the correlation between them and postoperative deep venous thrombosis in gynecologic oncology patients. Methods Tissue factor (TF) plasma levels of patients with deep venous thrombosis and postoperative patients with deep venous thrombosis after benign and malignant tumors were detected by ELISA respectively. Results The level of TF in gynecological malignant tumor without deep venous thrombosis was significantly higher than that in uterine fibroids and healthy controls (P <0.01). There was no significant difference in uterine fibroids and healthy controls (P> 0.05). The level of TF in deep vein thrombosis patients with gynecologic malignancy was significantly higher than that in uterine fibroids and healthy controls (P <0.01). The levels of TF in uterine leiomyoma were significantly different between gynecological malignant tumor group with deep venous thrombosis, gynecological malignant tumor group with uterine fibroids and no deep venous thrombosis (P <0.05). Conclusion Tissue factor in patients with deep venous thrombosis after gynecologic tumor was significantly higher. Tissue factor could be used as one of the indicators of postoperative deep venous thrombosis in gynecological tumors, especially gynecological malignancies.