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目的探讨儿童难治性癫癎(IE)的临床相关因素。方法采用回顾性分析的方法对38例IE患儿(IE组)与40例药物治疗有效的癫癎患儿(对照组)的临床资料(包括起病年龄、发作频率、发作形式、脑电图表现、头颅影像学改变、智能情况、家族史、服药依从性,对首次用药治疗的反应情况等)进行对比分析。结果 IE组1岁前的发病率、发作频率、出现多种发作形式和伴智能障碍率、头颅影像学及脑电图异常率均较对照组增高,差异均有统计学意义(Pa<0.05);IE组首次应用抗癫癎药物治疗反应不良、联合多种药物控制发作及药物治疗依从性差的概率较对照组亦增高,差异均有统计学意义(Pa<0.05)。结论儿童IE与发病年龄小、发作频繁、症状性癫癎或癫癎综合征、多种发作形式共存、伴智能障碍、头颅影像学及脑电图异常改变率高、首次应用抗癫癎药物治疗的反应差、联合多种药物治疗、药物治疗的依从性差等诸多因素有关。
Objective To investigate the clinically relevant factors of children refractory epilepsy (IE). Methods A retrospective analysis of 38 cases of children with IE (IE group) and 40 cases of drug-effective epilepsy in children (control group) clinical data (including onset age, frequency of seizures, seizures, EEG Performance, changes in head imaging, intelligence, family history, medication compliance, response to first-time medication, etc.) were analyzed. Results The incidence, frequency of seizures, multiple seizures and mental retardation, head imaging and EEG abnormalities in IE group were significantly higher than those in control group (P <0.05) In the first group, the adverse reactions of antiepileptic drug treatment in the first group were higher than those in the control group. The difference was statistically significant (P <0.05). Conclusion Children with age of onset of IE, frequent seizures, symptomatic epilepsy or epilepsy syndrome, a variety of seizures coexistence, with mental retardation, head imaging and abnormal changes in EEG, the first application of anti-epileptic drugs Poor response, combined with multiple drug treatment, drug treatment, poor compliance and many other factors.