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目的:了解不同人群在接种甲型H1N1流感疫苗1年后的特异性抗体水平及其差异,以及疫苗接种不良反应情况。方法:选择接种了1年时间的不同年龄段及不同性别的人群作为研究对象,取血样以“血凝抑制试验”进行甲型H1N1流感病毒特异性抗体滴度检测。结果:接种1年后人群的抗体阳性率(保护率)为76.78%,其中10岁～17岁及22岁～55岁两年龄组抗体阳性率(保护率)分别为61.84%和89.80%;不同性别抗体阳性率(及保护率)分别为男:78.95%、女:75.00%;接种不良反应率为4.17%。结论:接种甲型H1N1流澸疫苗后不良反应发生率低且无严重不良反应;接种1年后,疫苗对人群的保护作用无明显下降。
OBJECTIVE: To understand the level of specific antibodies and their differences after vaccination against influenza A (H1N1) in different populations for one year, as well as the adverse reactions of vaccination. Methods: The subjects of different age groups and different sexes who were inoculated for 1 year were selected as subjects, and the blood samples were tested for influenza A (H1N1) virus titer with “hemagglutination inhibition test”. Results: The antibody positive rate (protection rate) of the population after one year of inoculation was 76.78%. The positive rates (protection rates) of the two age groups 10 to 17 years old and 22 to 55 years old were 61.84% and 89.80% respectively; The positive rates (and protective rates) of sex antibody were 78.95% for males and 75.00% for females, respectively. The rate of adverse reactions in vaccination was 4.17%. Conclusion: The incidence of adverse reactions after vaccination with influenza A (H1N1) vaccine was low and no serious adverse reactions were observed. One year after inoculation, the protective effect of the vaccine on the population did not decrease significantly.