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目的探讨体外受精-胚胎移植(IVF-ET/ICSI)妊娠后发生早期流产的可能相关因素。方法将IVF或ICSI获得妊娠的735个周期,按妊娠结局分为早期流产组和继续妊娠组,分析IVF/ICSI妊娠后发生早期流产的可能相关因素。结果早期流产组患者年龄和胚胎移植数明显高于继续妊娠组(P<0.01);窦卵泡数、hCG日E2、P值、获卵数均明显低于继续妊娠组(P<0.01)。Logistic回归分析显示年龄增高及获卵数减少是发生早期自然流产的危险因素。结论 IVF/ICSI治疗周期中患者年龄、窦卵泡数、hCG日E2、P值、获卵数、移植胚胎数与早期流产相关,年龄增高及获卵数减少可增加早期自然流产风险。
Objective To investigate the possible related factors of early miscarriage after IVF-ET / ICSI pregnancy. Methods The 735 cycles of IVF or ICSI were divided into early miscarriage group and continuous pregnancy group according to the outcome of pregnancy. IVF or ICSI were analyzed for the possible related factors of early miscarriage after pregnancy. Results The age and the number of embryo transfer in the early abortion group were significantly higher than those in the continuing pregnancy group (P <0.01). The number of antral follicles, E2 and P values on the hCG day and the number of oocytes retrieved were significantly lower than those in the continuing pregnancy group (P <0.01). Logistic regression analysis showed that the increase of age and the reduction of the number of oocytes were the risk factors of early spontaneous abortion. Conclusions Age, antral follicle count, E2, P value, number of oocytes retrieved, number of transplanted embryos in IVF / ICSI treatment cycle are associated with early miscarriage. Increasing age and decreasing oocyte number may increase the risk of early spontaneous abortion.