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为探讨肾体积减少50%以上对残余肾功能和形态学的影响,作者对14例孤立肾部分切除者作了长期随访研究。14例男女各7例,年龄范围37～73岁,平均55岁,除1例外均为白种人。12例在2个月,21年(平均4.6年)前因同一种癌切除一侧肾脏,2例一侧肾先天性萎缩而无功能。孤立肾部分切除的原因:13例发生局限性肾细胞癌,1例患肾盂移行细胞癌。所有病人孤立肾部分切除前均无非恶性肾脏疾病,术前血清肌酸酐80～159μmol/升,平均109μmol/升。血压均正常,8例曾有高血压史,但均被药物控制,无服用血管紧张素转换酶抑制剂者。术后随访5～17年(平均7.7年)。
To investigate the effect of reducing renal volume by more than 50% on residual renal function and morphology, we performed a long-term follow-up study of 14 isolated solitary nephrectomies. Fourteen men and women each had seven cases, with an age range of 37-73 years, with an average of 55 years of age, with all but one being Caucasian. Twelve cases had resection of one kidney before the same kind of cancer at 2 months and 21 years (average 4.6 years), and 2 cases of one side kidney had congenital atrophy and no function. Isolated partial nephrectomy reasons: 13 cases of localized renal cell carcinoma, 1 case of renal pelvis transitional cell carcinoma. All patients with isolated nephrectomy before non-malignant kidney disease, preoperative serum creatinine 80 ~ 159μmol / l, an average of 109μmol / liter. Blood pressure were normal, 8 cases had a history of hypertension, but were controlled by drugs, without taking angiotensin-converting enzyme inhibitors. The patients were followed up for 5 to 17 years (average 7.7 years).