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目的探讨颈动脉硬化和C反应蛋白与急性脑梗死的关系。方法采用彩色多普勒超声检测86例急性脑梗死患者的颈动脉内膜,免疫比浊法测定其血清C反应蛋白水平,并与40例同期住院的非脑血管疾病患者作对照。结果脑梗死组颈动脉内膜斑块明显多于对照组(P<0.01),且以软斑和混合斑为主,而对照组以硬斑为主;脑梗死组C反应蛋白水平为9.85±2.28 mg/L,显著高于对照组的5.28±1.23 mg/L(P<0.01);软斑、混合斑、硬斑、正常颈动脉、内膜毛糙组C反应蛋白水平分别为9.80±2.43 mg/L、10.72±2.55 mg/L、7.46±2.54 mg/L、6.15±1.71 mg/L及6.38±1.96 mg/L。前两组与后三组比较均有显著性差异(P<0.01),后三组之间比较没有显著性差异。结论急性脑梗死患者颈动脉斑块明显增多,C反应蛋白水平明显升高,C反应蛋白水平可以反应颈动脉斑块的性质和稳定性。
Objective To investigate the relationship between carotid atherosclerosis and C-reactive protein and acute cerebral infarction. Methods The carotid intima of 86 patients with acute cerebral infarction was detected by color Doppler ultrasonography. Serum C - reactive protein level was measured by immunoturbidimetry and compared with 40 patients with non - cerebrovascular diseases hospitalized in the same period. Results The intima plaques of carotid artery in cerebral infarction group were significantly more than those in control group (P <0.01), and were predominantly in soft plaque and mixed plaque, while the control group was predominantly in hard plaque. The C-reactive protein level in cerebral infarction group was 9.85 ± 2.28 mg / L, which was significantly higher than that of the control group (5.28 ± 1.23 mg / L, P <0.01). The levels of C-reactive protein in the soft plaque, mixed plaque, sclerosis, normal carotid artery and endometrial rough group were 9.80 ± 2.43 mg /L, 10.72 ± 2.55 mg / L, 7.46 ± 2.54 mg / L, 6.15 ± 1.71 mg / L and 6.38 ± 1.96 mg / L, respectively. There were significant differences between the first two groups and the latter three groups (P <0.01), but the latter three groups showed no significant difference. Conclusion The carotid artery plaque in patients with acute cerebral infarction was significantly increased, the level of C-reactive protein was significantly elevated, and the level of C-reactive protein could reflect the nature and stability of carotid artery plaque.