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血管活性肠肽(vasoactive intestinal peptide,VIP)广泛存在于动物及人大脑、脊髓和周围神经中,在支配脑血管的神经中尤为丰富.本实验观察动物脑微血管中VIP的含量及其在急性脑缺血时的改变. 材料与方法 一、动物 Wistar雄性大鼠27只,200～321.5 g,沙土鼠22只,50～69.5 g,雄性,均由本院医学实验动物研究所提供. 二、脑缺血动物模型 Wistar大鼠经乌拉坦(1g/kg,ip)麻醉后,结扎双侧颈总动脉,通过小量放
Vasoactive intestinal peptide (VIP) is widely found in animals and human brains, spinal cord and peripheral nerves. It is particularly abundant in nerves that control cerebral blood vessels. This experiment observed the content of VIP in brain microvessels of animals and its effect on acute brain. Changes during ischemia. Materials and methods: Animals Wistar male 27 rats, 200-321.5 g, 22 gerbils, 50-69.5 g, male, provided by the Institute of Laboratory Animal Research in our hospital. Ischemic animal model Wistar rats were anesthetized with urethane (1g/kg, ip) and the bilateral common carotid arteries were ligated and passed through a small amount.