原发性下咽癌Cyclin-D_1基因的过度表达

• 出 处: 国外医学(耳鼻咽喉科学分册)
• 发表日期: 1998年01期
• 关键词: Cyclin-D_1 中分化癌 分化程度 高分化癌 头颈部鳞癌 中度阳性 细胞增殖 预后指标 颈部淋巴结转移 未分化癌

ＣｙＣｌｉｎ－ＤＩ原癌基因（ＣｙＣｌｌｆｉ－ＤＩ，ＰｒｏｔＯＯｌｌｃ。ｇｅｎｅ）的扩增和过度表达与头颈部鳞癌的发生有关。该文作者检查了４２例原发性下咽癌的ＣｙＣｌｉｎ－ＤＩ基因和细胞增殖标记物Ｋｉ－６７抗体。４２例患者中男３８例，女４例，平均年龄５９．５

The amplification and overexpression of CyClin-DI proto-oncogene (CyCllfi-DI, ProtOOllc.gene) are associated with the development of squamous cell carcinoma of the head and neck. The authors examined 42 cases of primary hypopharyngeal cancer CyClin-DI gene and cell proliferation marker Ki-67 antibody. Among the 42 patients, 38 were males and 4 were females, with an average age of 59.5