Hesperetin induces glyoxalase 1 enhancement in SH-SY5Y cells cultured with high glucose via Nrf2/ARE

• 作 者: ZHANG Meng-ya LIU Yao-wu
• 机 构: JiangsuKeyLaboratoryofNewDrugResearchandClinicalPharmacy,DepartmentofPharmacy,DepartmentofPharmacolo
• 出 处: 中国药理学与毒理学杂志
• 发表日期: 2019年9期
• 关键词: HESPERETIN NEUROPROTECTION GLYOXALASE 1 Nrf2/ARE pathway GSK-3Β
• 基金项目: National Natural Science Foundation of China(81371210).

OBJECTIVE To investigate the neuroprotective effects of hesperetin on central neurons under chronic high glucose,and the relationship to glyoxalase 1(Glo-1),a cytoprotective enzyme.METHODS The human neuroblas toma SH-SY5Y cells were divided into 5 groups: