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传统观念认为脂肪组织仅仅是储存机体能量的场所,随着近些年研究的不断深入,其活跃的内分泌功能逐渐被发掘,其所分泌的如瘦素、脂联素、网膜素、内脂素等脂肪因子通过内分泌、旁分泌和自分泌途径广泛参与调节机体诸多生理功能。网膜素是新近发现的一个特异性表达于网膜脂肪组织的细胞因子,众多研究发现网膜素在肥胖、糖尿病及心血管疾病等代谢领域广泛参与调节和维持糖、脂代谢平衡及血管内皮功能。已有研究报道网膜素1与代谢内分泌疾病如代谢综合征及多囊卵巢综合征关系密切,现对网膜素1及上述两者之间的关系研究综述如下。
The traditional concept that adipose tissue is only a place to store body energy, with the deepening of research in recent years, its active endocrine function gradually been discovered, which secreted, such as leptin, adiponectin, Adipokines such as adiponectin are widely involved in the regulation of many physiological functions through endocrine, paracrine and autocrine pathways. Operhin is a recently discovered cytokine that is specifically expressed in omental adipose tissue. Numerous studies have found that olanchurin is widely involved in the regulation and maintenance of glucose and lipid metabolism and vascular endothelium in the metabolic fields of obesity, diabetes and cardiovascular diseases Features. It has been reported that the relationship between retinol-1 and metabolic endocrine diseases such as metabolic syndrome and polycystic ovary syndrome is closely related to the relationship between retinal pigment epithelium 1 and the above two.