麝香酮在大鼠、家兔和狗体内的药代动力学

• 作 者: 朱耀伟 程桂芳 朱秀媛
• 机 构: 中国医学科学院药物研究所,中国医学科学院药物研究所,中国医学科学院药物研究所 北京 100050,北京 100050,北京 100050
• 出 处: 药学学报
• 发表日期: 1993年03期
• 关键词: 大鼠 家兔 麝香酮 三室开放模型 种属差异 药代动力学 二室开放模型 血浆样品 血药浓度 冠脉流量

麝香酮在大鼠体内的药时过程符合二室开放模型,在家兔和狗体内的药时过程则符合三室开放模型。大鼠、家兔和狗之间的药代动力学过程存在着显著的种属差异,大鼠iv麝香酮12,18和24 mg/kg三种剂量间的药代动力学主要参数无显著性差异。iv给药大鼠的T_(1/2)B为118.1～131.2min。家兔和狗的T_(1/2)B分别为24.9和30.0 min,T_(1/2)γ分别为331.9和366.4 min。大鼠、家兔和狗三b种动物的V_(?)分别为23.0,51.7和7.3 L/kg.V_(?)分别为2.33,2.13和0.38 L/kg。

Musk ketone in rats when the drug process in line with the two-compartment open model, in rabbits and dogs in the drug process is in line with the three-compartment open model. There were significant species differences in pharmacokinetics between rats, rabbits and dogs. There were no significant differences in the pharmacokinetics parameters between the three doses of iv musk ketone 12, 18 and 24 mg / kg difference. T_ (1/2) B of rats administered iv was 118.1 ~ 131.2 min. The T_ (1/2) B of rabbits and dogs were 24.9 and 30.0 min respectively, and the T_ (1/2) γ were 331.9 and 366.4 min, respectively. The V_ (?) Of rats, rabbits and dogs were 23.0, 51.7 and 7.3 L / kg, respectively, and the V_ (?) Were 2.33, 2.13 and 0.38 L / kg, respectively.