进口罗红霉素在健康人体内的药代动力学

• 作 者: 乔海灵 张莉蓉 张启堂 贾琳静 刘凤芝 马统勋
• 机 构: 河南医科大学临床药理学教研室
• 出 处: 河南医科大学学报
• 发表日期: 1998年03期
• 关键词: 药代动力学 药动学特点 二房室开放模型 体内过程 微机处理 微生物法 峰时间 药物浓度 时间数据 峰浓度

为探讨进口罗红霉素在国人体内的过程特点，对１６名男性健康志愿者单剂口服罗红霉素片剂后的药代动力学进行了研究。采用微生物法测定口服本品后不同时间血清中药物浓度，药时数据用３Ｐ８７软件经微机处理。结果：口服本品后的体内过程符合二房室开放模型，主要药动学参数，如峰时间、峰浓度、消除半衰期、药时曲线下面积分别为（１６７±０５７）ｈ、（８８０±１３０）ｍｇ／Ｌ、（１３８８±１３８）ｈ、（１０８７３±２００２）ｍｇ·ｈ·Ｌ－１。结果表明：国人罗红霉素药动学特点与国外报道相似

In order to explore the process characteristics of imported roxithromycin in Chinese people, the pharmacokinetics of single oral roxithromycin tablets in 16 male healthy volunteers were studied. Microbial method was used to determine the concentration of the drug in serum at different times after oral administration. The data of drugmediated drug was processed by computer with 3P87 software. Results: The in vivo process of oral administration of this product conformed to the two-compartment open model. The main pharmacokinetic parameters such as peak time, peak concentration, elimination half-life and area under the drugtime curve were (167 ± 057) h, (880 ± 130) mg / L, (1388 ± 138) h, (10873 ± 2002) mg · h · L-1. The results show that: people Roxithromycin pharmacokinetic characteristics and foreign reports similar