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敌枯双[N,N’-methylerie-bis-(α-amino-1,3,4-thiadiazole)、(MATDA)]以静脉注射、灌胃和喂饲给妊娠与雌、雄性猕猴染毒。结果:除喂饲组外,猕猴表现摄食差,萎靡和活动减少,进而呕吐、拒食和腹泻;孕猴出现流产或仔猴畸形;甲状腺病理变化明显,从滤泡增生至抑制,具剂量—反应关系。
Pregnant and female and male rhesus monkeys were injected intravenously, gavage and fed with N, N’-methylerie-bis- (α-amino-1,3,4-thiadiazole), (MATDA) Results: In addition to the feeding group, macaques showed poor feeding, sluggishness and activity reduction, vomiting, antifeedant and diarrhea; abortion or monkeys abortion in pregnant monkeys; obvious pathological changes of thyroid from follicular hyperplasia to inhibition with dose-response relationship.