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目的 探讨长期咀嚼槟榔对机体有无遗传毒性。方法 应用短期的体外、体内致突变试验检测槟榔的遗传效应。结果 槟榔剂量在３ ７５０、７ ５００ｍ ｇ／ｋｇ·ｂｗ 时，小鼠精子畸形率分别为１２４９％ 、１３９０％ ，极明显高于阴性对照组（１０３４％ ）（χ２ ＝ ２２８８，５９４９， Ｐ＜ ００１）。结论 槟榔能通过睾丸屏障影响小鼠的精子发育过程，对小鼠的生殖细胞有一定的遗传毒性。
Objective To investigate whether the long-term chewing betel nut has genetic toxicity to the body. Methods The short-term in vitro and in vivo mutagenicity tests were used to detect the genetic effects of areca. Results When the betel was dosed at 3 750 and 7 500 m g/kg bw, the abnormal rate of sperm in mice was 12 49% and 13 90% respectively, which was significantly higher than that of the negative control group (10 34%) (χ 2 = 22 88,5949, P< 001). Conclusion The betel nut can affect the sperm development of mice through the testis barrier and has certain genotoxicity to the germ cells of mice.