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药物的生物转化主要是在肝脏进行。肝脏催化药物生物转化的一个重要酶就是肝微粒体酶。它存在于肝平滑内质网内,是一种膜结合性具有多物质电子传递功能的体系。由于它能催化药物等外源性物质的代谢,所以也称肝微粒体药物代谢酶(简称“药酶”)。
Biotransformation of the drug is mainly carried out in the liver. An important enzyme in the biotransformation of liver-catalyzed drugs is liver microsomal enzymes. It is present in the smooth hepatic endoplasmic reticulum and is a membrane-binding system with multi-material electron transport. Because it can catalyze the metabolism of drugs and other exogenous substances, it is also called liver microsomal drug metabolism enzyme (referred to as “drug enzyme”).