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目的了解醋酸泼尼松联合环磷酰胺治疗甲亢浸润性突眼的临床效果。方法纳入2013年~2015年确诊为甲亢且伴有浸润性突眼症状患者80例为研究对象,根据治疗方案将其分为对照组(常规甲亢对症治疗)和观察组(甲亢治疗基础上应用醋酸泼尼松联合环磷酰胺),每组40例。对比2组患者临床治疗效果。结果对照组的治疗总有效为75.00%,低于观察组的92.50%,差异具有统计学意义(P<0.05);且经治疗后所有患者突眼度均在不同程度改善,且观察组改善效果更为明显(P<0.05)。结论甲亢浸润性突眼患者除常规治疗外,联合醋酸泼尼松、环磷酰胺等药物进行治疗,更能有效改善浸润性突眼症状。
Objective To investigate the clinical effect of prednisone acetate and cyclophosphamide in the treatment of hyperthyroidism-infiltrating exophthalmos. Methods Eighty patients with hyperthyroidism and infiltrative exophthalmos diagnosed from 2013 to 2015 were enrolled in this study. According to the treatment plan, they were divided into control group (conventional hyperthyroidism symptomatic treatment) and observation group (hyperthyroidism treatment based on acetic acid Prednisone combined cyclophosphamide), 40 cases in each group. The clinical effects of two groups were compared. Results The total effective rate of the control group was 75.00%, which was lower than that of the observation group (92.50%), the difference was statistically significant (P <0.05); and the degree of exophthalmos in all the patients was improved to some extent after treatment, and the improvement effect in the observation group More obvious (P <0.05). Conclusion Patients with hyperthyroidism infiltrative exophthalmos, in addition to conventional treatment, combined with prednisone acetate, cyclophosphamide and other drugs for treatment, more effective in improving the symptoms of infiltrative exophthalmos.