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目的 :探讨硫普罗宁对抗结核药所致轻、中度肝损害的疗效。方法 :抗结核药所致肝损害病人 98例 ,分成 2组 ,治疗组5 3例 ,不停用抗结核药 ,加用硫普罗宁注射液 0 2g ,静脉滴注 ,每日 1次 ,连用 4周。对照组 45例 ,停用抗结核药且不用硫普罗宁。两组均采用基础治疗 (肌苷、维生素B1 )。结果 :两组临床总有效率分别为 94 3 4%和 71 11% (P <0 0 1) ,治疗组中ALT、AST、γ -GT、AKP和TB治疗前后的测定值差异有显著性 (P <0 0 5 ) ,分别为ALT173± 5 0与 48± 16U·L- 1 ;AST13 2± 3 6与 5 3± 42U·L- 1 ;γ -GT93± 3 2与 61± 8U·L- 1 ;AKP168± 43与 12 0± 2 3U·L- 1 ;TB70± 48与 2 1± 5 μmol·L- 1 。治疗组各项肝功能指标明显优于对照组 (P<0 0 1)。结论 :硫普罗宁对抗结核药所致的轻、中度肝损害有明显的治疗作用
Objective: To investigate the efficacy of tiopronin in the treatment of mild to moderate hepatic injury caused by antituberculosis drugs. Methods: 98 cases of liver damage caused by anti-tuberculosis drugs were divided into 2 groups, 53 cases in the treatment group. The anti-tuberculosis drugs were not stopped. The animals were given 0.2 g of tiopronin injection intravenously once daily. 4 weeks. Control group of 45 patients, disable anti-TB drugs and not sulfur protonine. Both groups were treated with basic (inosine, vitamin B1). Results: The total effective rates of the two groups were 94.3% and 71.11%, respectively (P <0.01). There were significant differences in the measured values of ALT, AST, γ-GT, AKP and TB before and after treatment P <0.05), which were ALT173 ± 50 and 48 ± 16U · L -1, AST13 2 ± 36 and 53 ± 42 U · L -1, γ -GT93 ± 32 and 61 ± 8U · L- 1; AKP168 ± 43 and 12 0 ± 2 3U · L-1; TB70 ± 48 and 2 1 ± 5 μmol·L-1. The indexes of liver function in the treatment group were significantly better than those in the control group (P <0.01). Conclusion: Tiopronin has a significant therapeutic effect on mild and moderate hepatic injury caused by anti-tuberculosis drugs