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药物在体内的代谢过程是多种多样的,但主要是通过肝脏(部分在其他组织)的降解及肾脏的排泄。药物经肝脏代谢,一部分被灭活,一部分代谢物仍具有药理活性,许多药物不经代谢而以原型由肾脏排泄。当肾功能不全时机体会发生一系列的药理动力学变化,如药物的吸收、运输、分布容积、代谢率和排泄率等的改变。这些改变主要反映在病人对药物的毒性副反应上,所以在肾功能不全时必须很好地了解掌
The metabolism of drugs in the body is varied, but mainly through the degradation of the liver (partly in other tissues) and the excretion of the kidneys. Drugs are metabolized by the liver, some are inactivated, and some metabolites are still pharmacologically active. Many drugs are excreted by the kidneys without metabolism. When the renal insufficiency occurs when the body will experience a series of pharmacokinetic changes, such as drug absorption, transport, distribution volume, metabolic rate and excretion rate changes. These changes are mainly reflected in the patient’s toxic side effects on drugs, so in renal insufficiency must be a good understanding of the palm