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外周T细胞淋巴瘤,非特指型(peripheralT-celllymphoma-unspecified,PTCL-U)是新近WHO淋巴肿瘤病理分类中一个较新的亚型。它是起源于胸腺后T淋巴细胞的一类恶性肿瘤。病因不清,可能与Epstein-Barrvirus(EBV)和人类T细胞白血病/淋巴瘤病毒-Ⅰ(HTLV-Ⅰ)有关。其诊断需结合临床、细胞形态、免疫及遗传学特征,并排除其它特指型T细胞淋巴瘤。常规化疗疗效不佳,易复发,5年生存率22%～27%,应寻找更有效的治疗方法。
Peripheral T-cell lymphoma-unspecified (PTCL-U) is a relatively new subtype in the pathological classification of the newly identified lymphoma of the WHO. It is a group of malignant tumors that originate in the posterior thymic T lymphocytes. The etiology may be related to Epstein-Barr virus (EBV) and human T cell leukemia / lymphoma virus-I (HTLV-I). The diagnosis should be combined with clinical, cell morphology, immune and genetic features, and exclude other specific T-cell lymphoma. Conventional chemotherapy ineffective, easy to relapse, 5-year survival rate of 22% to 27%, should find more effective treatment.