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目的:探讨干扰素联合布地奈德治疗毛细支气管炎的疗效。方法:将153例婴幼儿毛细支气管炎患儿随机分为治疗组和对照组。治疗组给予干扰素联合布地奈德雾化治疗,对照组给予利巴韦林联合地塞米松雾化治疗;两组均辅以退热、止咳及必要时抗生素等对症支持治疗。比较两组患儿治疗后发热、喘息、肺部哮鸣音情况、住院天数以及随访2年后喘息症状的再发生率和平均发生次数(次/人·年-1)。结果:两组治疗后发热、喘息、肺部哮鸣音明显缓解,治疗组症状缓解速度、程度均优于对照组(P<0.05),住院天数少于对照组(P<0.05);治疗组2年后随喘息症状再发生率和平均发生次数明显低于对照组。结论:干扰素联合布地奈德治疗毛细支气管炎疗效肯定,能迅速缓解和控制临床症状,减少喘息再发生率和平均发生次数。
Objective: To investigate the efficacy of interferon combined with budesonide in the treatment of bronchiolitis. Methods: 153 infants with bronchiolitis were randomly divided into treatment group and control group. The treatment group was given interferon combined with budesonide atomization, the control group was given ribavirin combined with dexamethasone atomization; both groups were supplemented with antipyretic, cough and antibiotics and other symptomatic supportive treatment. The incidences of fever, wheezing, wheezing in the lungs, days of hospitalization, and recurrence of wheezing after 2 years of follow-up were compared between two groups of children (mean / person / year -1). Results: The fever, wheezing and lung wheezing were relieved after treatment in both groups. The symptom relieving rate and degree in the treatment group were better than those in the control group (P <0.05), and the days of hospitalization were shorter than those in the control group (P <0.05) Two years later with wheezing symptoms reoccurrence rate and the average number of occurrence was significantly lower than the control group. Conclusion: The combination of interferon and budesonide is effective in treating bronchiolitis, which can quickly relieve and control the clinical symptoms, reduce the recurrence of wheezing and the average number of occurrence.