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目的:研究血清Ⅳ型胶原在慢性肝病上的诊断价值并与血清层粘蛋白、透明质酸比较.方法:用放免法(RIA)测定114例各种肝病患者及30例正常对照者的血清Ⅳ型胶原、层粘蛋白和透明质酸的水平.结果:与正常对照比较慢性肝炎、肝硬化和肝细胞癌患者血清Ⅳ型胶原含量升高极显著(P<0.01),层粘蛋白和透明质酸含量亦显著升高(P<0.05).与慢性肝炎、肝硬化比较肝细胞癌患者血清中Ⅳ型胶原含量升高明显(P<0.05);结沦:血清Ⅳ型胶原为判断肝纤推化的良好指标.
Objective: To investigate the diagnostic value of serum type Ⅳ collagen in chronic liver disease and to compare with serum laminin and hyaluronic acid.Methods: The serum levels of serum Ⅳ in 114 patients with various liver diseases and 30 normal controls were determined by radioimmunoassay (RIA) Collagen, laminin and hyaluronic acid.Results: Compared with the normal control group, the serum level of type Ⅳ collagen in patients with chronic hepatitis, cirrhosis and hepatocellular carcinoma increased significantly (P <0.01), laminin and hyaluronan (P <0.05) .Compared with chronic hepatitis and cirrhosis, the serum level of type Ⅳ collagen in patients with hepatocellular carcinoma increased significantly (P <0.05) .Conclusion: A good indicator of