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目的 研究组织蛋白酶D(Cath -D)和PCNA表达与食管癌分级、浸润、转移和预后的关系 ,以及Cath -D和PCNA表达的相互关系。方法 应用微波 -SP免疫组化法 ,检测 65例食管鳞状细胞癌组织中Cath -D和PCNA表达水平。结果 在食管癌中Cath -D和PCNA表达阳性率分别为 64 6%和 69 2 %。Cath -D和PCNA表达均与肿瘤分级、浸润、淋巴结转移和预后相关。Cath -D和PCNA表达呈正相关。结论 Cath -D和PCNA是食管癌高度恶性和预后不良的重要生物学指标。食管癌Cath -D和PCNA表达具有相互协同作用可能。
Objective To investigate the relationship between the expression of cathepsin D (Cath-D) and PCNA and the classification, invasion, metastasis and prognosis of esophageal cancer and the relationship between the expression of Cath-D and PCNA. Methods The expression of Cath-D and PCNA in 65 cases of esophageal squamous cell carcinoma was detected by microwave-SP immunohistochemistry. Results The positive rates of Cath-D and PCNA expression in esophageal cancer were 64 6% and 69 2% respectively. Cath-D and PCNA expression were related to tumor grade, invasion, lymph node metastasis and prognosis. Cath-D and PCNA expression was positively correlated. Conclusions Cath-D and PCNA are important biomarkers of esophageal cancer with high malignancy and poor prognosis. Cath-D and PCNA expression of esophageal cancer may have synergistic effect with each other.