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目的探讨安庆农村地区男性人群吸烟状态与认知功能的关系及其影响因素。方法研究对象来自2013年8月6日~24日在安庆地区农村人群中进行的流行病学调查。通过问卷收集受试者简易精神状态(mini-mental state examination,MMSE)评分、吸烟信息和其他相关变量,采用多元线性回归模型评估吸烟与MMSE评分的关联。结果 615例男性受试者纳入最终分析。调整年龄、教育程度、血压、体质指数、生活习惯、饮酒、卒中史和抑郁评分后,与从不吸烟者(24.4±5.0)相比,吸烟者(以前或现在吸烟者)(24.8±4.7)(β=0.72,sx-=0.35,P=0.038)MMSE评分增加。在文盲人群,以前吸烟(22.3±4.6)(β=1.62,sx-=0.83,P=0.05)和现在吸烟者(21.9±4.8)(β=1.36,sx-=0.68,P=0.046)与从不吸烟者(20.8±4.8)相比,MMSE评分明显增加;而在不同年龄分层,二者未见明显差异。结论吸烟与MMSE评分呈显著正相关,且在文盲人群中更为明显。
Objective To explore the relationship between smoking status and cognitive function in male population and its influencing factors in rural Anqing. METHODS Subjects were from the epidemiological survey conducted in rural areas in Anqing from August 6 to August 24, 2013. Multivariate linear regression models were used to assess associations of smoking with MMSE scores by collecting subjects’ mini-mental state examination (MMSE) scores, smoking information and other relevant variables. Results 615 male subjects were included in the final analysis. Smokers (former or current smokers) (24.8 ± 4.7) compared with those who never smoked (24.4 ± 5.0) after adjusting for age, education, blood pressure, body mass index, lifestyle, alcohol consumption, stroke history and depression scores (β = 0.72, sx- = 0.35, P = 0.038) MMSE score increased. In the illiterate population, previous smoking (22.3 ± 4.6) (β = 1.62, sx- = 0.83, P = 0.05) and current smoker (21.9 ± 4.8) (β = 1.36, sx- = 0.68, P = 0.046) Compared with non-smokers (20.8 ± 4.8), MMSE score increased significantly; however, there was no significant difference between the two groups at different ages. Conclusion There was a significant positive correlation between smoking and MMSE score, and more obvious in illiterate people.