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目的探讨抑癌基因PTEN在人宫颈癌组织中的表达及其与宫颈癌发生、发展的关系。方法应用免疫组织化学方法检测正常宫颈组织、宫颈上皮内瘤样病变(CINⅠ、CINⅡ、CINⅢ)、宫颈癌组织中PTEN的表达情况。结果PTEN蛋白在正常宫颈、CINⅠ、CINⅡ、CINⅢ、宫颈癌组织中表达率逐渐下降,各组与宫颈癌组比较,差异均有统计学意义;正常宫颈和CINⅠ与CINⅢ组比较,差异均有统计学意义。PTEN蛋白表达与宫颈癌临床分期和淋巴结转移具有相关性,与宫颈癌病理学分级无关。结论抑癌基因PTEN参与宫颈癌的发生发展。
Objective To investigate the expression of tumor suppressor gene PTEN in human cervical cancer and its relationship with the occurrence and development of cervical cancer. Methods Immunohistochemistry was used to detect the expression of PTEN in normal cervical tissue, cervical intraepithelial neoplasia (CINⅠ, CINⅡ, CINⅢ) and cervical cancer. Results The expression of PTEN protein in normal cervix, CINⅠ, CINⅡ, CINⅢ and cervical cancer tissues decreased gradually. There was significant difference between each group and cervical cancer group. There was statistical difference between normal cervix, CINⅠand CINⅢgroup Significance of learning. PTEN protein expression and clinical stage and lymph node metastasis of cervical cancer has nothing to do with the pathological grade of cervical cancer has nothing to do. Conclusion The tumor suppressor gene PTEN is involved in the development of cervical cancer.