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目的探讨伤寒菌株耐药谱及当地诊所使用的 7个厂家 12个批号治疗用药氟哌酸的疗效。方法应用琼脂扩散法 ,对 5株伤寒杆菌用 12种抗菌素及氟哌酸胶囊自制的纸片进行药敏测定。结果本次流行中分离的菌株具有多重耐药 ,对氯霉素、羧苄青霉素、氨苄青霉素耐药 ,对氟哌酸、庆大霉素、丁胺卡拉、头孢三嗪、头孢克罗敏感。在 12个批号的氟哌酸中 ,有 3个批号的氟哌酸与标准氟哌酸纸片两者的抑菌环大小有明显差异。结论 1998年贵州省威宁县爆发流行中所分离的伤寒菌具有多重耐药性。规范药品进货渠道保证药品质量至关重要。
Objective To investigate the drug resistance spectrum of typhoid strains and the efficacy of norfloxacin in 12 batches of 7 batches used by local clinics. Methods The agar diffusion method was used to determine the susceptibility of 5 Salmonella typhimurium isolates to 12 homemade antibiotics and norfloxacin capsules. Results The strains isolated from this epidemic were multi-drug resistant, resistant to chloramphenicol, carbenicillin and ampicillin, and sensitive to norfloxacin, gentamicin, butylamine, ceftriaxone and cefaclor. Of 12 batches of norfloxacin, there were significant differences in the size of the zone of inhibition of both the 3 norfloxacin and standard norfloxacin sheets. Conclusion The typhus isolated from epidemic outbreak in Weining County of Guizhou Province in 1998 was multidrug-resistant. Standardize the drug purchase channels to ensure drug quality is essential.