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22例伴有Ⅰ期慢性脑病的酒精性肝硬化门诊病人,戒酒已有1年以上,均在服用乳果糖,并限制饮食中的蛋白质为40g/d已数月。把病人分为锌治疗组10例,安慰剂对照组12例。两组的年龄、性别、血清胆红素和Child氏分级均无差异。给每例病人21颗胶囊,每颗胶囊含醋酸锌200mg或含安慰剂,每日3次,每次1颗,连用7天。试验前后测定血尿素氮以及血清铜和锌。至第8天复查时锌治疗组的肝性脑病有明显改善,血尿素氮和血清锌比治疗前明显增加,
Twenty-two outpatients with alcoholic cirrhosis with stage I chronic encephalopathy had abstinence for more than one year, both taking lactulose and limiting the dietary protein to 40 g / d for several months. The patients were divided into zinc treatment group 10 cases and placebo control group 12 cases. There were no differences in age, sex, serum bilirubin, and Child’s grade in both groups. To each patient 21 capsules, each capsule containing zinc acetate 200mg or placebo, 3 times a day, each 1, once every 7 days. Blood urea nitrogen and serum copper and zinc were measured before and after the test. By the 8th day of review, there was a significant improvement in hepatic encephalopathy in the zinc treatment group, blood urea nitrogen and serum zinc were significantly increased compared with before treatment,