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目的：为了解母婴淋病瑟菌（Ng）、解脲脲原体（Uu）、沙眼衣原体（Ct）[以下简称NUC]的感染状况，并探讨其与异常妊娠和不良妊娠结局的关系。方法：应用套式PCR检测了210例母婴的宫颈脱落细胞、羊水、新生儿咽拭子3种标本中NUC特异性DNA。结果：1．210例母婴标本NUC联检单项阳性为35．2％、2项阳性为10．0％、3项阳性为1．00％，NUC总阳性率46．2％；2．由胎儿宫内生长迟缓、胎膜早破、早产、死胎、畸胎所构成的115例异常妊娠组NUC阳性率达66．1％，明显高于正常妊娠组的22．1％（P＜0．01）；3．新生儿NUC阳性者平均出生体重和Apger评分明显低于阴性者（P均＜0．05）。我国母婴NUC感染率较高。NUC感染与胎儿宫内生长迟缓、胎膜早破、早产、死胎、畸胎相关联并致不良妊娠结局。
Objective: To investigate the infection status of Ng, Uu and Ct [NUC] in maternal and neonates, and to explore the relationship between abnormal pregnancy and adverse pregnancy outcome. Methods: Nested PCR was used to detect NUC specific DNA in 210 specimens of cervical exfoliated cells, amniotic fluid and throat of neonates. Results: The positive rate of NUC in 1.210 maternal and infant samples was 35.2%, 2 positives were 10.0%, 3 positives were 1.00%, and the positive rate of NUC was 46.2%. The positive rate of NUC in 115 cases of abnormal pregnancy, which was caused by fetal growth retardation, premature rupture of membranes, premature labor, stillbirth and teratology, was 66.1%, which was significantly higher than that of normal pregnancy group (22.1%, P <0 .01); 3. Neonatal NUC positive average birth weight and Apger score was significantly lower than negative (P <0.05). China’s mother and child NUC infection rate higher. NUC infection and fetal growth retardation, premature rupture of membranes, premature birth, stillbirth, teratogenic and cause adverse pregnancy outcomes.