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目的 研究丙泊酚全身麻醉过程对水杨酸钠排泄的影响及其机制.方法 麻醉前,取雄性SD大鼠16只,腹腔注射1％水杨酸钠80 mg· kg-1后,收集尿液,记录实际排尿时间和尿量.用光谱法测定尿液中水杨酸浓度,绘制尿药浓度-时间曲线.经3d清洗期,上述大鼠尾静脉注射丙泊酚150 mg·kg-1后,立即腹腔注射水杨酸钠,方法同前.绘制麻醉前与麻醉后尿药浓度-时间曲线,代入药代动力学分析软件3P97,计算尿药代动力学参数,比较麻醉前与麻醉后水杨酸钠排泄能力的变化.眶静脉丛取血检测血气指标,并进行血气指标与水杨酸累积排泄量相关分析.结果 丙泊酚麻醉前与麻醉后,pH分别为7.44±0.04,7.37±0.06;二氧化碳分压(PCO2)分别为(39.58±6.42),(47.71±6.80)mmHg;氧分压(PO2)分别为(88.25±6.80),(67.75±3.73)mmHg;剩余碱(BE)分别为(1.20±1.05),(-5.08±1.88)mmol·L-1;最大排泄率(Rmax)分别为(0.62±0.15),(0.39±0.04)mg·h-1;Cmax分别为(1.43±0.23),(0.85±0.15)mg·kg-1;0～28h排泄-时间曲线下面积(ERUC 0-28)分别为(25.83±3.8),(17.35±2.01)mg·h·L-1,差异有统计学意义(均P ＜0.05).pH、PO2、BE与水杨酸累积排泄量呈明显正相关,相关系数(R2)分别为0.9758,0.9760,0.9398;而PCO2与水杨酸累积排泄量呈明显反正相关,R2为0.9023,差异有统计学意义(P＜0.05).结论 丙泊酚静脉麻醉能减慢大鼠水杨酸钠排泄速度,与血气指标显著相关.“,”Objective To explore the effects of propofol intravenous anesthesia on the excretion of sodium salicylate and its mechanism in rats.Methods A total of 16 male SD rats were placed in rat metabolic cage to collect urine after intraperitoneal injection of 1％ sodium salicylate 80 mg · kg-1.Then the actual time urination and urinary volume were recorded.And salicylic acid concentration in urine were determine by spectrometry.Urine drug concentration-time curve were drawed.After 3 days of cleaning period,the rats were given intravenous injection of propofol 150 mg · kg-1 immediately after intraperitoneal injection of sodium salicylate with the former method.Urine drug concentration-time curve were drewed before and after anesthesia.Urine drug metabolism and pharmacokinetics parameters were analyzed with 3P97 Software.Sodium salicylate excretion capacity was analyzed before and after anesthesia.In experiment 3 h,the blood gas indexes were detected in the orbital venous plexus.After 3 h,blood from orbital venous was collected for analyzing the parameters of blood gas.And then,blood gas index and salicylic acid accumulation correlation analysis was eliminated.Results pH were 7.44 ± 0.04,7.37 ± 0.06 respectively before or after anesthesia by propofol intravenous.Partial pressure of carbon dioxide (PCO2) were (39.58 ± 6.42),(47.71 ± 6.80) mmHg respectively.Partial pressure of oxygen (PO2) were (88.25 ± 6.80),(67.75 ± 3.73) mmHg respectively.Base excess (BE) were (1.20 ± 1.05),(-5.08 ± 1.88) mmol · L-1 respectively.Maximum excretory rate (Rmax) were (0.62 ± 0.15),(0.39 ± 0.04) mg· h-1 respectively.Cmax were (1.43 ± 0.23),(0.85 ± 0.15) mg · kg-1 respectively.Excretion under curve (ERUC 0-28) were (25.83 ± 3.8),(17.35 ± 2.01) mg · h · L-1 respectively,the difference was statistically significant (all P ＜0.05).Statistically significant positive correlation was presented between pH,PO2,BE and accumulated with salicylic acid excretion (P ＜ 0.05).And R2 were respectively 0.9758,0.9760,0.9398.At the same time,the obvious negative correlation was observed between PCO2 and salicylic acid accumulation excretion,R2 was 0.902 3,it was statistical significance (P ＜0.05).Conclusion Propofol intravenous anesthesia can slow down the rate of sodium salicylate excretion,and significantly related to parameters of blood gas.