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目的:探讨临床代谢综合征及其组分与子宫内膜癌的相关性,从而为预防妇科肿瘤提供参考。方法:回顾2012年3月至2015年3月西安交通大学第一医院术中及术后病理确诊为子宫内膜癌病例258例数,对照组为同时期体检的年龄、月经匹配的非妇科肿瘤人群。代谢综合征采用2005年国际糖尿病联盟(IDF)定义。所有数据资料采用统计软件SPSS11.5进行统计分析。结果:1子宫内膜癌组代谢综合征发病率为38.0%,明显高于对照组为10.9%,P<0.05,2组比较差异有统计学意义。代谢综合征的组分:腰围、BMI、SBP、DBP、FPG、TG、总胆固醇水平明显高于对照组,P<0.05,差异有统计学意义。HDL-C明显低于对照组,P<0.05,差异有统计学意义。2子宫内膜癌合并代谢综合征独立危险因素:腰围、DBP、TG,OR值分别为:5.254,1.069,3.019。结论:1代谢综合征及其组分:腰围、BMI、SBP、DBP、FPG、TG、总胆固醇与子宫内膜癌的发病具有相关性。2子宫内膜癌合并代谢综合征独立危险因素:腰围、DBP、TG。
Objective: To investigate the correlation between clinical metabolic syndrome and its components and endometrial cancer, so as to provide a reference for the prevention of gynecological tumors. Methods: From March 2012 to March 2015, 258 cases of endometrial cancer were diagnosed intraoperatively and postoperatively in the First Hospital of Xi’an Jiaotong University. The control group consisted of the same age, menstrual non-gynecologic cancer crowd. Metabolic syndrome is based on the 2005 International Diabetes Federation (IDF) definition. All data using statistical software SPSS11.5 statistical analysis. Results: 1 The incidence of metabolic syndrome in endometrial cancer group was 38.0%, which was significantly higher than that in the control group (10.9%, P <0.05). There was significant difference between the two groups. The components of metabolic syndrome: waist circumference, BMI, SBP, DBP, FPG, TG, total cholesterol levels were significantly higher than the control group, P <0.05, the difference was statistically significant. HDL-C was significantly lower than the control group, P <0.05, the difference was statistically significant. 2 endometrial cancer with metabolic syndrome independent risk factors: waist circumference, DBP, TG, OR values were: 5.254,1.069,3.019. Conclusion: 1 Metabolic syndrome and its components: waist circumference, BMI, SBP, DBP, FPG, TG, total cholesterol and the incidence of endometrial cancer has a correlation. 2 endometrial cancer with metabolic syndrome independent risk factors: waist circumference, DBP, TG.