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【目的】探讨宫内缺氧对新生儿红细胞渗透脆性的影响。【方法】选择湘雅医院2012～2013年新生儿科27例无新生儿窒息的住院患儿，根据出生前有无缺氧病史将患儿分为对照组（ n ＝20）和宫内缺氧组（ n ＝7）。于生后1 h内抽取动脉血进行血气、乳酸（LA）和微量血胆红素（BIL）测定，生后24 h内抽取静脉血进行红细胞渗透脆性的测定。【结果】宫内缺氧组出生时 Apgar 评分，血液 pH 值，动脉二氧化碳分压（PaCO2）与对照组差异无显著性（ P＞0．05），但其动脉氧分压（PaO2）、动脉血样饱和度（SaO2）和微量血BIL明显低于对照组（ P ＜0．05～0．01），而血L A浓度明显高于对照组（ P ＜0．01）；当溶血率分别为20％、50％、80％和90％时，宫内缺氧组所需NaCl缓冲液浓度均明显低于对照组（ P ＜0．05～0．01），而当溶血率分别为10％和100％时，宫内缺氧组所需NaCl缓冲液浓度与对照组相比显差无异统计学意义（ P ＞0．05）。【结论】宫内缺氧可引起新生儿红细胞的渗透脆性降低。“,”[Objective]To explore the impact of intrauterine hypoxia on erythrocyte osmotic fragility in newbo-rns .[Methods]Totally 27 newborns without neonatal asphyxia in department of neonatology of Xiangya hospital from 2012~2013 were selected .According to the history of intrauterine hypoxia before birth ,all patients were divided into control group( n=20) and intrauterine hypoxia group ( n=7) .Arterial blood samples were extracted within 1h after birth to detect blood gas ,lactic acid(LA) and minimal bilirubin(BIL) .Venous blood was drawn within 24h to detect erythrocyte osmotic fragility .[Results]There was no significant difference in Apgar score ,pH and PaCO2 between in-trauterine hypoxia group and control group ( P>0 .05) .PaO2 ,SaO2 and minimal BIL in intrauterine hypoxia group were obviously lower than those in control group ( P<0 .01~0 .05) ,but LA level in intrauterine hypoxia group was obviously higher than that in control group ( P<0 .01) .When hemolysis ratio was 20% ,50% ,80% and 90% re-spectively ,NaCl buffer solution concentration in intrauterine hypoxia group was lower than that in control group ( P0 .05) .[Conclusion]Intrauterine hypox-ia can decrease erythrocyte osmotic fragility in newborns .