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90年代后期以来,对SIRS炎性反应的机制进行了更深入的研究,得到一些宝贵的新认识,尤其在细胞炎性信号转导和细胞周期调控机制方面,并提出对ARDS、SIRS、MODS、CARS等重症疾患认识的新概念——统属“炎性免疫信号转导紊乱疾患”。近年来,炎症信号转导领域的几个重大突破.如Toll受体的发现,MAPK通路的初步阐明,NF-κB活性调控机制及免疫细胞凋亡机制的新认识等,涉及到从胞膜→胞质→胞核信号转导全过程,使我们看到了炎性重症治疗的曙光。虽然我们尚未彻底认识炎症反应本质。但目前的进步已经大大不同于以往的抗细胞外介质治疗时代,似乎标志着一个新的里程碑,进入胞内信号和细胞周期调控的新阶段。随着我们对炎症机制认识的不断深入,将为危急疾患的早期诊断提供更敏感的信号指标,也必将指导产生全新的治疗理念和更有效的治疗策略。
Since the late 1990s, the mechanisms of SIRS inflammatory response have been studied in more depth, and some valuable new insights have been gained, especially in the mechanism of cellular inflammatory signal transduction and cell cycle regulation. The mechanisms of ARS, SIRS, MODS, CARS and other new concepts of critical illness awareness - all belong to “inflammatory immune signal transduction disorders.” In recent years, several major breakthroughs in the field of inflammatory signal transduction, such as the discovery of Toll receptor, the preliminary elucidation of MAPK pathway, the regulatory mechanism of NF-κB activity and the new understanding of the immune cell apoptosis mechanism, Cytoplasmic → nuclear signal transduction of the whole process, so that we see the dawn of severe inflammatory treatment. Although we have not completely understood the nature of the inflammatory response. But the current advances have been vastly different from previous anti-ECM therapies and seem to mark a new milestone in the new phase of intracellular signaling and cell-cycle regulation. As we continue to deepen our understanding of the mechanism of inflammation, we will provide more sensitive signals for the early diagnosis of critical illnesses and will also guide the creation of new treatment concepts and more effective treatment strategies.