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目的 研究大剂量黄连素对 2型糖尿病患者血液流变学的影响。方法 随机选择 6 0岁以上 2型糖尿病患者 112例 ,所有病例用二甲双呱进行常规降糖治疗 ,其中 78例同时服用黄连素 40d ,34例同时用川芎嗪静脉滴注 2个疗程 (2 0d) ,分别检测用药前、后血液流变学 (包括血小板膜糖蛋白 ,简称CD6 2 ) ,并同时对血糖、血脂进行观察。结果 黄连素和川芎嗪治疗后 ,血液流变学各指标均较治疗前明显下降 (P <0 0 1)。表明黄连素和川芎嗪可明显改善血液粘度和减少红细胞和血小板聚集。其中 ,黄连素治疗后在降低血浆粘度、降低红细胞聚集指数、红细胞压积、纤维蛋白元及血糖等方面比川芎嗪组更明显 (P <0 0 1)。结论 大剂量黄连素及川芎嗪均有明显改善糖尿病患者的血液流变学 ,且黄连素对降低血浆粘度、红细胞聚集、纤维蛋白元及降低血糖方面优于川芎嗪
Objective To study the effect of high dose berberine on hemorheology in type 2 diabetic patients. Methods A total of 112 patients with type 2 diabetes mellitus were randomly selected over the age of 60 years. All patients were treated with metformin for conventional hypoglycemic treatment. Among them, 78 patients received berberine 40 days at the same time, while 34 patients received intravenous infusion of ligustrazine twice a day 0d). Blood rheology (including platelet membrane glycoprotein, CD6 2 for short) was measured before and after treatment, and blood glucose and blood lipids were observed at the same time. Results After treatment with berberine and ligustrazine, the indexes of hemorheology were significantly lower than those before treatment (P <0.01). Berberine and ligustrazine can significantly improve blood viscosity and reduce red blood cell and platelet aggregation. Among them, berberine treatment was more obvious than the ligustrazine group in reducing plasma viscosity, reducing erythrocyte aggregation index, hematocrit, fibrin and blood glucose (P <0.01). Conclusion Both high-dose berberine and ligustrazine can significantly improve the hemorrheology in patients with diabetes, and berberine is superior to tetramethylpyrazine in lowering plasma viscosity, erythrocyte aggregation, fibrin and lowering blood glucose