论文部分内容阅读
广西南宁邕江药业有限公司生产的国家新药赖诺普利胶囊是用于治疗高血压、充血性心力衰竭和急性心肌梗死。原胶囊剂的含量及含量均匀度测定按卫生部试行标准采用HPLC法。由于HPLC法较繁琐,易于损害柱子,且重现性较差,难于适合工厂大量长期测定。经试验赖诺普利易溶于水,其水溶液在205nm处具有稳定的紫外吸收峰,故采用紫外分光光度法进行含量及含量均匀度测定。方法准确可靠,操作简便亦易于普及,结果满意。
Guangxi Nanning Qijiang Pharmaceutical Co., Ltd. production of national new drug lisinopril capsules are used for the treatment of hypertension, congestive heart failure and acute myocardial infarction. Determination of the content of the original capsules and content uniformity by the Ministry of Health trial standards using HPLC method. Due to the cumbersome HPLC method, easy to damage the column, and poor reproducibility, it is difficult for a large number of long-term determination of the factory. The tested lisinopril soluble in water, its aqueous solution has a stable UV absorption peak at 205nm, so the determination of content and content uniformity by UV spectrophotometry. The method is accurate and reliable, easy to operate and easy to popularize, the result is satisfactory.