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许多格兰氏阴性细菌产生β-内酰胺酶。众所周知,产生这种酶和β-内酰胺抗生素的耐药性是密切相关的。这样就引起人们对酶抑制剂作为β-内酰胺抗生素的保护剂的兴趣。以前的研究报告中,我们已经叙述了一组产生九种β-内酰胺酶的菌种。这些菌株的
Many Gram-negative bacteria produce beta-lactamase. It is well-known that the resistance to produce this enzyme and beta-lactam antibiotics is closely related. This has led to interest in enzyme inhibitors as protective agents for [beta] -lactam antibiotics. In previous studies, we have described a group of strains that produce nine beta-lactamases. These strains