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目的探讨埃索美拉唑三联疗法治疗十二指肠球部溃疡的效果。方法将78例十二指肠球部溃疡患者随机分为埃索美拉唑治疗组和奥美拉唑对照组,分别给予埃索美拉唑三联疗法和奥美拉唑三联疗法,疗程7d。结果治疗组和对照组溃疡愈合率分别为92%(36/39)和90%(35/39),2组间差异无统计学意义(P>0.05);幽门螺杆菌(Hp)根除率分别为82%(32/39)和80%(31/39),2组间差异无统计学意义(P>0.05);前3d腹痛症状改善率治疗组明显高于对照组,差异有统计学意义(P<0.05);且2组均无明显不良反应。结论埃索美拉唑和奥美拉唑治疗十二指肠溃疡均有良好的疗效,而埃索美拉唑缓解症状作用较奥美拉唑更为明显,值得临床推广。
Objective To investigate the effect of esomeprazole triple therapy on duodenal ulcer. Methods A total of 78 patients with duodenal ulcer were randomly divided into esomeprazole group and omeprazole control group. Esomeprazole triple therapy and omeprazole triple therapy were given respectively for 7 days. Results The healing rates of ulcer in the treatment group and the control group were 92% (36/39) and 90% (35/39) respectively, with no significant difference between the two groups (P> 0.05). The rates of H. pylori (Hp) Were 82% (32/39) and 80% (31/39) respectively. There was no significant difference between the two groups (P> 0.05). The improvement rate of first trimester abdominal pain in treatment group was significantly higher than that in control group (P <0.05). There was no significant adverse reaction in both groups. Conclusions Both esomeprazole and omeprazole have good efficacy in the treatment of duodenal ulcer. Esomeprazole is more effective in relieving symptoms than omeprazole, which is worthy of clinical promotion.