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目的:分析北京积水潭医院碳青霉烯类抗菌药物致药品不良反应(ADR)的发生特点,为临床合理用药提供参考。方法:采用回顾性分析的方法 ,对该院2005─2015年上报的52例碳青霉烯类抗菌药物引发的ADR,分别从性别、年龄、原发疾病、涉及药品、累及器官或系统、临床表现、临床转归等方面进行统计、分析。结果:52例患者中男性37例(71.15%)、女性15例(28.85%);18~60岁年龄段ADR发生率最高;主要原发疾病为呼吸系统疾病、骨骼肌肉损伤和全身性损伤;主要累及器官或系统为皮肤及附件和神经系统;77.55%的患者于停药后症状完全消失。结论:临床使用碳青霉烯类抗菌药物时应监测、减少ADR的发生,提高用药合理性。
Objective: To analyze the characteristics of adverse drug reaction (ADR) induced by carbapenem antibiotics in Beijing Jishuitan Hospital, and provide a reference for clinical rational drug use. Methods: A retrospective analysis was conducted on 52 cases of carbapenem-based ADRs reported from 2005 to 2015 in this hospital from gender, age, primary disease, drug involved, organ or system involved, Performance, clinical outcome and other aspects of statistics, analysis. Results: Among the 52 patients, 37 (71.15%) were male and 15 (28.85%) were female. The incidence of ADR was the highest among 18-60 years old. The main primary diseases were respiratory diseases, skeletal muscular injury and general injury. The main organ or system involved the skin and accessories and the nervous system; 77.55% of patients completely disappeared after stopping the symptoms. Conclusion: The use of carbapenem antibiotics in clinical monitoring should be monitored to reduce the incidence of ADR and improve the rationality of medication.