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多药耐药性（ MDR）肿瘤动物模型是攻克肿瘤耐药性的基础，同时在逆转肿瘤耐药性的药物筛选研究中也起重要作用，因此，优越的MDR肿瘤动物模型在科学研究中具有很高的应用价值。目前，MDR肿瘤动物模型主要通过移植、诱导和体内外联合诱导3种方法构建。该文通过对MDR肿瘤动物模型资料进行归纳和总结，对这3种方法进行了详细的表述和评价，并对MDR肿瘤动物模型的评价方法进行了简要的叙述。“,”Multidrug resistant( MDR) tumor animal model is fundamental to overcome tumor resistance , which also plays a crucial role in the drug screening study about effectively reversing drug resistance in a variety of tumors,therefore,the value of superior MDR animal model is even more prominent in scientific research.So far,transplantation,induction and combination of in vitro and in vivo induction ,are three meth-ods to build the MDR tumor animal models .Here is to summarize the data about MDR tumor animal models , and the three methods are described and evaluated in detail , the evaluation method of MDR tumor animal models is briefly described as well.