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目的 探讨膀胱移行细胞癌中血管内皮生长因子(VEGF)和碱性成纤维细胞生长因子(bFGF)的表达与临床病理指标和预后的关系。方法 应用免疫组织化学方法,对62例原发性膀胱移行细胞癌组织中VEGF和bFGF进行检测。结果 膀胱癌组织中VEGF和bFGF阳性表达率分别为56.5％和46.8％。VEGF和bFGF表达与膀胱癌的病理分级、临床分期、复发及3年生存率密切相关。结论 VEGF和bFGF表达对膀胱癌生物学行为有重要影响,VEGF和bFGF表达有可能成为预测膀胱癌复发、转移和预后的指标。
Objective To investigate the relationship between the expression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in bladder transitional cell carcinoma and clinicopathological parameters and prognosis. Methods Immunohistochemistry was used to detect VEGF and bFGF in 62 cases of primary bladder transitional cell carcinoma. Results The positive rates of VEGF and bFGF in bladder cancer tissues were 56.5% and 46.8% respectively. The expression of VEGF and bFGF is closely related to the pathological grade, clinical stage, recurrence and 3-year survival rate of bladder cancer. Conclusions The expressions of VEGF and bFGF have an important influence on the biological behavior of bladder cancer. The expression of VEGF and bFGF may be the predictors for the recurrence, metastasis and prognosis of bladder cancer.