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目的:观察当归补血汤加味对大鼠运动病条件性厌食症模型的治疗作用。方法:大鼠禁水24小时后给药,30分钟后采用旋转刺激装置持续刺激30分钟诱发大鼠条件性厌食症模型,造模结束30分钟后给予0.15%糖精水,测量各大鼠45分钟内的饮用量;脱颈椎处死动物,取大脑,分离海马组织,测定丙二醛(MDA)、总超氧化物歧化酶(T-SOD)、一氧化氮(NO)。结果:当归补血汤加味高、中剂量组与模型组45分钟内糖精水的饮用量比较有统计学意义(P<0.05);当归补血汤高、中剂量组的T-SOD含量与模型组比较有统计学意义(P<0.05);当归补血汤高、中剂量组的MDA含量与模型组比较有统计学意义(P<0.05);各治疗组的NO含量与模型对照组比较,均有上升趋势,但无统计学意义(P>0.05)。结论:当归补血汤加味对大鼠运动病条件性厌食症模型有一定治疗作用。
Objective: To observe the therapeutic effect of Dangguibuxuetang on the condition-induced anorexia model in rats. Methods: Rats were administered with water for 24 hours after water forbidden. After 30 minutes, rats were subjected to continuous stimulation with a rotary stimulator for 30 minutes to induce conditioned anorexia model. After 30 minutes of modeling, 0.15% saccharin was given to rats, and each rat was measured for 45 minutes The animals were sacrificed by cervical dislocation, the brain was taken and the hippocampus was separated for determination of MDA, T-SOD and NO. Results: The drinking amount of saccharin in water of Dangguibuxuetang plus high and middle dose group and model group within 45 minutes was statistically significant (P <0.05); Compared with model group, the content of T-SOD of Dangguibuxuetang group was higher (P <0.05). The content of MDA in Dangguibuxuetang group was higher than that of the model group (P <0.05). The content of NO in each treatment group increased compared with the model control group Trend, but not statistically significant (P> 0.05). Conclusion: Modified Danggui Buxue decoction has a certain therapeutic effect on the condition-based anorectic model of motion sickness in rats.