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用(30)~Rb摄入法研究了人红细胞钠泵的阳离子转运活性。在实验的最适条件下,测定了正常人70例红细胞钠泵活性,其值为0.449±0.059mmol/(L·h)(X±SD)。在此基础上观察了大黄液在体外对人红细胞钠泵活性的抑制作用。讨论了大黄降温机理与大黄抑制钠泵的关系。研究提示了钠泵活性异常在细胞产热的病理生理学上的可能作用。
The cation transport activity of human RBC sodium pump was studied by (30) Rb uptake method. Under the optimum conditions of the experiment, the activity of sodium pump of red blood cells in 70 cases of normal people was measured, and the value was 0.449±0.059 mmol/(L·h)(X±SD). On this basis, we observed the inhibitory effect of rhubarb on the activity of sodium pump in human erythrocytes in vitro. The mechanism of cooling mechanism of rhubarb and the relationship between rhubarb inhibition and sodium pump were discussed. Studies have suggested the possible role of sodium pump activity in the pathophysiology of cell heat production.