大鼠D-氨基半乳糖中毒后肝细胞超微结构及G-6-P酶活性的变化

• 作 者: 金永三 贲长恩 王德福
• 机 构: 北京中医学院组织学胚胎学教研室,北京中医学院组织学胚胎学教研室,北京中医学院组织学胚胎学教研室 北京针灸骨伤学院组织学胚胎学教研室 北京 100015
• 出 处: 解剖学报
• 发表日期: 1992年04期
• 关键词: 细胞超微结构 G-6-P 大鼠 磷酸酶活性 肝损伤 肝细胞 细胞化学 损伤组 滑面内质网 次级溶酶体

在大鼠腹腔内注射D-氨基半乳糖造成肝损伤后,电镜下观察肝细胞超微结构和葡萄糖-6-磷酸酶活性变化。结果表明,损伤组肝细胞中常染色质减少,核仁颗粒部消失,粗面内质网扩张,核糖体脱落,数量减少,滑面内质网扩张,其切面呈小泡状,次级溶酶体增多,糖原颗粒消失,葡萄糖-6-磷酸酶活性下降。本文为进一步探讨D-氨基半乳糖造成肝损伤的机理,提供了一些新的资料。

After liver injury induced by intraperitoneal injection of D-galactosamine in rats, the ultrastructure of hepatic cells and glucose-6-phosphatase activity were observed under electron microscope. The results showed that in the injured group, the number of hepatic cells was decreased, the nucleolus granuloma disappeared, the rough endoplasmic reticulum was expanded, the number of ribosomes was decreased, the number of glomerulus was decreased, the endoplasmic reticulum expanded, the section was vesicular, Increased body, glycogen particles disappear, glucose-6-phosphatase activity decreased. In this paper, to further explore the mechanism of D-galactosamine caused liver damage, provide some new information.