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目的:为探讨埃索美拉唑联合抗生素治疗幽门螺杆菌(Hp)感染消化性溃疡的疗法。方法:将符合条件的122例病人,随机分为埃索美拉唑三联治疗组(A组)和奥美拉唑三联对照组(B组)。治疗4周后,复查胃镜并检测Hp,观察两组溃疡愈合率及Hp根治率。结果:A组和B组Hp根治率分别为92.31%(60/65)和91.23%(52/57),两组比较无统计学差异(P> 0.05)。A组和B组溃疡愈合率比较无统计学差异(P>0.05)。结论:埃索美拉唑三联疗法能有效的清除Hp及提高溃疡愈合率,是一种根治坳有高效、副作用少的药物。
Objective: To investigate the treatment of peptic ulcer with Helicobacter pylori (Hp) in combination with esomeprazole and antibiotics. Methods: 122 eligible patients were randomly divided into esomeprazole triple therapy group (group A) and omeprazole triple control group (group B). After 4 weeks of treatment, gastroscopy was performed and Hp was examined. The healing rate of ulcer and the cure rate of Hp in both groups were observed. Results: The cure rates of Hp in group A and group B were 92.31% (60/65) and 91.23% (52/57), respectively. There was no significant difference between the two groups (P> 0.05). There was no significant difference in the healing rate between group A and group B (P> 0.05). Conclusion: Esomeprazole triple therapy can effectively remove Hp and improve the healing rate of ulcer. It is a kind of medicine with high efficiency and few side effects.