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目的:探讨检测糖化血红蛋白(HbAlc)与糖化血清蛋白(GSP)对于妊娠糖尿病诊断的临床价值。方法:选择2010年2月～2012年2月确诊为妊娠糖尿病(GDM)的78例孕妇作为观察组,并选择80例正常妊娠的孕妇作为对照组,比较两组血清HbAlc和GSP水平,以及两组病例中HbAlc、GSP异常人数所占比例,并且对HbAlc、GSP在妊娠糖尿病诊断中的特异度、灵敏度、可靠度以及阳性预测值进行比较。结果:两组病例血清HbAlc和GSP水平均具有统计学差异(P<0.05),观察组检测指标均高于对照组;观察组病例HbAlc、GSP异常率均明显高于对照组(P<0.05);GSP在妊娠糖尿病诊断中的特异度、灵敏度、可靠度以及阳性预测值优于HbAlc,分别为97.00%、89.50%、92.00%、98.00%。结论:妊娠糖尿病患者血清HbAlc和GSP水平与正常妊娠孕妇有着明显不同,并且HbAlc和GSP在妊娠糖尿病诊断中的可靠度都比较高,尤其是GSP,说明HbAlc和GSP对妊娠糖尿病诊断有着重要的临床意义,值得推广使用。
Objective: To investigate the clinical value of detecting glycosylated hemoglobin (HbAlc) and glycosylated serum protein (GSP) in the diagnosis of gestational diabetes mellitus. Methods: Seventy eight pregnant women diagnosed with gestational diabetes mellitus (GDM) from February 2010 to February 2012 were selected as the observation group and 80 pregnant women as normal controls were selected as the control group. The levels of HbA1c and GSP in the two groups were compared, Group HbAlc, the proportion of GSP abnormalities in the proportion of HbAlc, GSP in gestational diabetes diagnosis of specificity, sensitivity, reliability and positive predictive value were compared. Results: The serum levels of HbA1c and GSP in both groups were significantly different (P <0.05), and the detection indexes in the observation group were higher than those in the control group. The abnormal rates of HbA1c and GSP in the observation group were significantly higher than those in the control group (P <0.05) The specificity, sensitivity, reliability and positive predictive value of GSP in gestational diabetes mellitus were better than HbAlc, which were 97.00%, 89.50%, 92.00% and 98.00% respectively. Conclusion: The serum levels of HbA1c and GSP in pregnant women with gestational diabetes mellitus are significantly different from those in normal pregnant women, and the reliability of HbA1c and GSP in the diagnosis of gestational diabetes are high, especially GSP, indicating that HbA1c and GSP have important clinical significance in the diagnosis of gestational diabetes Meaning, it is worth to promote use.