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目的探讨一氧化氮（ＮＯ）和降钙素基因相关肽（ＣＧＲＰ）在偏头痛发病机制中的作用。方法采用分光光度法和放免法，对偏头痛发作期２６例、间歇期２３例，其他头痛患者２７例及正常人２０例颈静脉（ＥＪＶ）和肘静脉（ＣＦ）血中ＮＯ和ＣＧＲＰ进行了测定。结果偏头痛发作组ＥＪＶ和ＣＦ血中ＮＯ含量均较正常人显著升高（Ｐ均＜０．０１）；偏头痛发作组ＥＪＶ血中ＣＧＲＰ含量明显升高（Ｐ＜０．０１），而ＣＦ血中两组间无显著差异（Ｐ＞０．０５）。结论ＮＯ和ＣＧＲＰ在偏头痛的发病机制中起重要作用。
Objective To investigate the role of nitric oxide (NO) and calcitonin gene related peptide (CGRP) in the pathogenesis of migraine. Methods Using spectrophotometry and radioimmunoassay, 26 patients with migraine, 23 patients with intermittent period, 27 patients with other headache and 20 normal subjects were selected for the study of NO and CGRP in the jugular vein (EJV) and cubital vein (CF) Determination. Results The levels of NO in both EJV and CF blood in migraine attack group were significantly higher than those in normal subjects (P <0.01). CGRP levels in EJV blood were significantly increased in migraine attack group (P <0.01) There was no significant difference between the two groups in blood (P> 0.05). Conclusion NO and CGRP play an important role in the pathogenesis of migraine.