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目的 研究系膜增生性肾炎患儿肾组织血小板源性生长因子 (PDGF)及其受体 (PDGFR α、β)的表达及意义。方法 采用免疫组化染色法检测弥漫性系膜增生性肾小球肾炎 (MsPGN)、局灶性节段性肾小球硬化(FSGS)肾活检组织中PDGF、PDGFR的表达。结果 PDGF在MsPGN中的表达明显高于正常肾和FSGS ,PDGFR α、β的表达高于正常肾 (P <0 0 1) ;PDGF在FSGS中的表达与正常肾相比无差异 ,但PDGFR α、β表达升高 (P <0 0 1) ;MsPGN与FSGS的PDGFR α、β表达无明显差异 (P >0 0 5 )。 结论 肾组织PDGF及其受体的过度表达可能在MsPGN的发病中起重要作用
Objective To investigate the expression and significance of platelet derived growth factor (PDGF) and its receptor (PDGFR α, β) in children with mesangial proliferative glomerulonephritis. Methods Immunohistochemical staining was used to detect the expression of PDGF and PDGFR in diffuse mesangial proliferative glomerulonephritis (MsPGN) and focal segmental glomerulosclerosis (FSGS) biopsies. Results The expression of PDGF in MsPGN was significantly higher than that in normal kidneys and FSGS. The expression of PDGFR α and β was higher than that in normal kidneys (P <0.01). PDGF expression in FSGS was not significantly different from that in normal kidneys (P <0.01). There was no significant difference in the expression of PDGFRα and β between MsPGN and FSGS (P> 0.05). Conclusion The overexpression of PDGF and its receptor in renal tissue may play an important role in the pathogenesis of MsPGN