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目的评价化疗并用微卡治疗复治涂阳肺结核的效果。方法将病人随机分为微卡加化疗治疗组与单纯化疗对照组,观察治疗结束肺部病灶吸收、空洞闭合及痰菌阴转情况。结果满疗程痰菌阴转率分别为93.5%和75.6%,治疗组高于对照组,两组比较,差异有统计学意义(P<0.01)。治疗组与对照组肺部病灶吸收率分别为84.8%和48.9%,空洞闭合率为60.9%和37.8%,两者比较差异有统计学意义,P<0.01及P<0.05。结论微卡能提高痰菌阴转率,有助于病灶吸收,可作为复治涂阳肺结核的免疫治疗和化疗的辅助治疗。
Objective To evaluate the effect of chemotherapy and micro-card therapy on smear-positive pulmonary tuberculosis. Methods The patients were randomly divided into micro-card plus chemotherapy group and chemotherapy alone group to observe the end of the treatment of lung lesions absorption, empty closure and sputum negative conversion. Results The full course of sputum negative conversion rate was 93.5% and 75.6%, the treatment group than the control group, the difference between the two groups was statistically significant (P <0.01). The absorption rates of lung lesions in treatment group and control group were 84.8% and 48.9% respectively, and the void closure rates were 60.9% and 37.8% respectively. There was significant difference between the two groups (P <0.01 and P <0.05). Conclusion Micro-card can improve the sputum negative conversion rate, which can help the lesion to be absorbed, and can be used as an adjuvant therapy for immunotherapy and chemotherapy of retreatment smear-positive pulmonary tuberculosis.